Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity | Zendy

Avry Chagnac | Zendy; Boris Zingerman | Zendy; Benaya RozenZvi | Zendy; Michal HermanEdelstein | Zendy

Open Access

Consequences of Glomerular Hyperfiltration: The Role of Physical Forces in the Pathogenesis of Chronic Kidney Disease in Diabetes and Obesity

Author(s) -

Avry Chagnac,

Boris Zingerman,

Benaya RozenZvi,

Michal HermanEdelstein

Publication year - 2019

Publication title -

the nephron journals/nephron journals

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.951

H-Index - 72

eISSN - 2235-3186

pISSN - 1660-8151

DOI - 10.1159/000499486

Subject(s) - glomerular hyperfiltration , medicine , podocyte , glomerular basement membrane , kidney disease , endocrinology , diabetes mellitus , renal function , diabetic nephropathy , kidney , glomerulonephritis , proteinuria

Glomerular hyperfiltration (GH) is a hallmark of renal dysfunction in diabetes and obesity. Recent clinical trials demonstrated that SGLT2 inhibitors are renoprotective, possibly by abating hyperfiltration. The present review considers the current evidence for a cause-to-effect relationship between hyperfiltration-related physical forces and the development of chronic kidney disease (CKD).

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