Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages | Zendy

Kimihiro Igari | Zendy; Matthew Kelly | Zendy; Dai Yamanouchi | Zendy

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Digoxin Attenuates Receptor Activation of NF-κB Ligand-Induced Osteoclastogenesis in Macrophages

Author(s) -

Kimihiro Igari,

Matthew Kelly,

Dai Yamanouchi

Publication year - 2019

Publication title -

journal of vascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.58

H-Index - 74

eISSN - 1423-0135

pISSN - 1018-1172

DOI - 10.1159/000499380

Subject(s) - digoxin , activator (genetics) , rankl , downregulation and upregulation , receptor , chemistry , pharmacology , signal transduction , endocrinology , medicine , microbiology and biotechnology , biology , biochemistry , heart failure , gene

Even though hypoxia-inducible factor-1α (HIF-1α) is among the transcriptional factors demonstrated to contribute to the formation of abdominal aortic aneurysms (AAAs), the precise mechanism has been unclear. Digoxin is known as an inhibitor of HIF-1α, and shows a protective effect against the progression of AAAs.

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