Open AccessHistone Deacetylase Inhibitors Reduce Cysts by Activating Autophagy in Polycystic Kidney Disease
Author(s) -
Liping Sun,
Chaofeng Hu,
Xinzhou Zhang
Publication year - 2019
Publication title -
kidney diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9381
pISSN - 2296-9357
DOI - 10.1159/000499368
Subject(s) - autophagy , autosomal dominant polycystic kidney disease , pkd1 , ampk , trichostatin a , polycystic kidney disease , cancer research , histone deacetylase , chemistry , kidney , medicine , microbiology and biotechnology , endocrinology , biology , apoptosis , kinase , protein kinase a , histone , biochemistry , gene
Histone deacetylase inhibitors (HDACi) have therapeutic effects on various models of renal diseases including autosomal dominant polycystic kidney disease (ADPKD), but the molecular mechanism is unclear.
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