ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion | Zendy

Lei Lang | Zendy; Yixuan Hou | Zendy; Yanlin Chen | Zendy; Gang Tu | Zendy; Jing Tao | Zendy; Dan Yang | Zendy; Lei Xi | Zendy; Lixin Fu | Zendy; Kexin Sun | Zendy; Jiali Yin | Zendy; Rui Chen | Zendy; Meixi Peng | Zendy; Shuiqing Liu | Zendy; Manran Liu | Zendy

Open Access

ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion

Author(s) -

Lei Lang,

Yixuan Hou,

Yanlin Chen,

Gang Tu,

Jing Tao,

Dan Yang,

Lei Xi,

Lixin Fu,

Kexin Sun,

Jiali Yin,

Rui Chen,

Meixi Peng,

Shuiqing Liu,

Manran Liu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000496048

Subject(s) - cortactin , microbiology and biotechnology , phosphorylation , cell migration , biology , cancer research , focal adhesion , kinase , invadopodia , cancer cell , chemistry , cytoskeleton , cell , cancer , biochemistry , genetics

The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still unclear.

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