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Wnt-5a Promotes Neural Development and Differentiation by Regulating CDK5 via Ca2+/Calpain Pathway
Author(s) -
Yang Shu,
Min Xiang,
Pei Zhang,
Guangjian Qi,
Feng He,
Qian Zhang,
Zheng Zhang,
Zexi Lv,
Xiang Peng,
Hongwei Cai,
Bo Tian
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000495932
Subject(s) - wnt signaling pathway , microbiology and biotechnology , cyclin dependent kinase 5 , biology , calpain , cellular differentiation , cyclin dependent kinase , signal transduction , kinase , cell cycle , cyclin dependent kinase 2 , cell , protein kinase a , biochemistry , gene , enzyme
The Wnt signaling pathway has essential functions in the central nervous system, where it regulates the major physiological functions of neurons, including development, differentiation, and plasticity. Wnt signaling controls these cellular events; however, how Wnt pathways integrate into a coherent developmental program remains unclear.

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