Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging | Zendy

Meihua Gong | Zendy; Pan Zhang | Zendy; Chunyang Li | Zendy; Xu Ma | Zendy; Daping Yang | Zendy

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Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging

Author(s) -

Meihua Gong,

Pan Zhang,

Chunyang Li,

Xu Ma,

Daping Yang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495902

Subject(s) - photoaging , stem cell , stem cell factor , microbiology and biotechnology , biology , stem cell marker , immunology , progenitor cell , genetics

Skin photoaging is primarily caused by the functional attrition of skin stem cells. The skin stem cell niche plays an important role in maintaining stem cell survival and behaviour. In our study, we hypothesized that UVB irradiation induces skin photoaging by changing skin stem cell niches and that transferred adipose-derived stem cells (ADSCs) can remodel the niches by affecting the BMP signalling pathway and transdifferentiating into skin stem cells.

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