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PGK1 is a Potential Survival Biomarker and Invasion Promoter by Regulating the HIF-1α–Mediated Epithelial-Mesenchymal Transition Process in Breast Cancer
Author(s) -
Deyuan Fu,
Chunlan He,
Jinli Wei,
Zhengquan Zhang,
Yulin Luo,
Haosheng Tan,
Chuanli Ren
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000495900
Subject(s) - breast cancer , gene knockdown , epithelial–mesenchymal transition , cancer research , cancer , biomarker , medicine , gene silencing , oncology , glycolysis , metastasis , downregulation and upregulation , stage (stratigraphy) , biology , cell culture , gene , metabolism , paleontology , biochemistry , genetics
Glycolysis, a multi-step enzymatic reaction, is considered to be the root of cancer development and progression. The aim of this study is to figure out which glycolysis enzyme participates in the progression of breast cancer and its possible mechanisms.

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