Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway | Zendy

Xue Mei Zhang | Zendy; Xi Xiong | Zendy; Chao Tong | Zendy; Qin Li | Zendy; Shuai Huang | Zendy; Qing Shu Li | Zendy; Ya Ming Liu | Zendy; Hai Ying Li | Zendy; Philip N. Baker | Zendy; Nan Shan | Zendy; Hong Qi | Zendy

Open Access

Down-Regulation of Laminin (LN)- α5 is Associated with Preeclampsia and Impairs Trophoblast Cell Viability and Invasiveness Through PI3K Signaling Pathway

Author(s) -

Xue Mei Zhang,

Xi Xiong,

Chao Tong,

Qin Li,

Shuai Huang,

Qing Shu Li,

Ya Ming Liu,

Hai Ying Li,

Philip N. Baker,

Nan Shan,

Hong Qi

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495822

Subject(s) - trophoblast , pi3k/akt/mtor pathway , biology , andrology , viability assay , placenta , apoptosis , preeclampsia , cell growth , microbiology and biotechnology , signal transduction , medicine , fetus , pregnancy , genetics , biochemistry

Preeclampsia (PE) is a gestational disorder defined as hypertension and proteinuria, which is deemed a major cause of maternal and neonatal mortality and morbidity worldwide. The aim of this study was to investigate the expression patterns of placental laminin (LN)-α5 expression in normal and PE pregnancies, as well as evaluating the effects of LN-α5 on trophoblast proliferation, apoptosis, and invasion.

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