Open AccessA Novel Model of Chronic Kidney Disease in Rats: Dietary Adenine in Combination with Unilateral Nephrectomy
Author(s) -
Cristina Muñoz Abellán,
Sandra MangoldGehring,
S. Micus,
Gerald Beddies,
Andreas Moritz,
Elke Hartmann,
Waldemar Lehmann,
Frank Eitner
Publication year - 2019
Publication title -
kidney diseases
Language(s) - English
Resource type - Journals
eISSN - 2296-9381
pISSN - 2296-9357
DOI - 10.1159/000495750
Subject(s) - medicine , kidney disease , nephrectomy , renal function , kidney , proteinuria , hyperphosphatemia , endocrinology , pathological , physiology , urology
Adenine at 0.75% in the diet (AD) triggers renal impairment in rats. This model of kidney disease is largely reversible when AD feeding is stopped. Testing of novel drugs parallel to AD administration may result in unwanted interference.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom