Inhibition of microRNA-200a Upregulates the Expression of Striatal Dopamine Receptor D2 to Repress Apoptosis of Striatum via the cAMP/PKA Signaling Pathway in Rats with Parkinson’s Disease | Zendy

DongMei Wu | Zendy; Shan Wang | Zendy; Xin Wen | Zendy; XinRui Han | Zendy; YongJian Wang | Zendy; Min Shen | Zendy; ShaoHua Fan | Zendy; Juan Zhuang | Zendy; Zi-Feng Zhang | Zendy; Qun Shan | Zendy; MengQiu Li | Zendy; Bin Hu | Zendy; Chunhui Sun | Zendy; Jun Lü | Zendy; YuanLin Zheng | Zendy

Open Access

Inhibition of microRNA-200a Upregulates the Expression of Striatal Dopamine Receptor D2 to Repress Apoptosis of Striatum via the cAMP/PKA Signaling Pathway in Rats with Parkinson’s Disease

Author(s) -

DongMei Wu,

Shan Wang,

Xin Wen,

XinRui Han,

YongJian Wang,

Min Shen,

ShaoHua Fan,

Juan Zhuang,

Zi-Feng Zhang,

Qun Shan,

MengQiu Li,

Bin Hu,

Chunhui Sun,

Jun Lü,

YuanLin Zheng

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495649

Subject(s) - homovanillic acid , tyrosine hydroxylase , dopamine receptor d2 , dopamine , glutathione peroxidase , creb , chemistry , tunel assay , dopaminergic , striatum , endocrinology , medicine , pharmacology , superoxide dismutase , apoptosis , biology , receptor , oxidative stress , biochemistry , transcription factor , gene , serotonin

Parkinson's disease (PD) is a neurodegenerative movement disease with a high annual incidence. Accumulating evidence demonstrates that microRNAs play important roles in the pathogenesis of multiple neurological disorders, including PD. This study aims to investigate how microRNA-200a (miR-200a) regulates striatal dopamine receptor D2 (DRD2) to affect apoptosis of striatum in rats with PD and to explore the associated mechanism.

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