Open AccessEFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction
Author(s) -
Letizia Albarrán,
José J. López,
Isaac Jardín,
José Sánchez-Collado,
Alejandro BernaErro,
Tarik Smani,
Pedro J. Camello,
Ginés M. Salido,
Juan A. Rosado
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000495494
Subject(s) - orai1 , stim1 , nfat , immunoprecipitation , cytosol , microbiology and biotechnology , biology , chemistry , biochemistry , endoplasmic reticulum , transcription factor , gene , enzyme
STIM1 and Orai1 are the key components of store-operated Ca2+ entry (SOCE). Among the proteins involved in the regulation of SOCE, SARAF prevents spontaneous activation of SOCE and modulates STIM1 function.
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