miR-16-2* Interferes with WNT5A to Regulate Osteogenesis of Mesenchymal Stem Cells | Zendy

Lijun Duan | Zendy; He Zhao | Zendy; Yang Xiong | Zendy; Xiangsheng Tang | Zendy; Yongdong Yang | Zendy; Zhenguo Hu | Zendy; Chuanhong Li | Zendy; Sixue Chen | Zendy; Xing Yu | Zendy

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miR-16-2* Interferes with WNT5A to Regulate Osteogenesis of Mesenchymal Stem Cells

Author(s) -

Lijun Duan,

He Zhao,

Yang Xiong,

Xiangsheng Tang,

Yongdong Yang,

Zhenguo Hu,

Chuanhong Li,

Sixue Chen,

Xing Yu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495489

Subject(s) - osteoblast , mesenchymal stem cell , osteoporosis , wnt signaling pathway , cancer research , stem cell , microrna , bone remodeling , downregulation and upregulation , chemistry , microbiology and biotechnology , endocrinology , medicine , biology , signal transduction , gene , biochemistry , in vitro

Osteoporosis is a bone metabolic disease characterized by a systemic impairment of bone mass, which results in increased propensity of fragility fractures. A reduction in the differentiation of MSCs into osteoblasts contributes to the impaired bone formation observed in osteoporosis. Mesenchymal stem cells (MSCs) are induced to differentiate into preosteoblasts, which are regulated by the signaling cascades initiated by the various signals, including miRNAs. miR-16-2* is a newly discovered miRNA that participates in diagnosis and prognosis of hepatocellular carcinoma, cervical cancer and chronic lymphocytic leukemia. However, the effect of miR-16-2* on the regulation of osteoblast differentiation and the mechanism responsible are still unclear. Here we discuss the contribution of miR-16-2* to osteoporosis, osteoblast differentiation and mineralization.

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