Interferon Consensus Sequence-Binding Protein 8, a Tumor Suppressor, Suppresses Tumor Growth and Invasion of Non-Small Cell Lung Cancer by Interacting with the Wnt/β-Catenin Pathway | Zendy

Lin Ye | Zendy; Tingxiu Xiang | Zendy; Jing Zhu | Zendy; Dairong Li | Zendy; Qin Shao | Zendy; Weiyan Peng | Zendy; Jun Tang | Zendy; Lili Li | Zendy; Guosheng Ren | Zendy

Open Access

Interferon Consensus Sequence-Binding Protein 8, a Tumor Suppressor, Suppresses Tumor Growth and Invasion of Non-Small Cell Lung Cancer by Interacting with the Wnt/β-Catenin Pathway

Author(s) -

Lin Ye,

Tingxiu Xiang,

Jing Zhu,

Dairong Li,

Qin Shao,

Weiyan Peng,

Jun Tang,

Lili Li,

Guosheng Ren

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495399

Subject(s) - wnt signaling pathway , suppressor , cancer research , beta catenin , catenin , biology , interferon , lung cancer , cell growth , signal transduction , cancer , microbiology and biotechnology , medicine , immunology , pathology , genetics

Interferon consensus sequence-binding protein 8 (IRF8) belongs to a family of interferon (IFN) regulatory factors that modulates various important physiological processes including carcinogenesis. As reported by others and our group, IRF8 expression is silenced by DNA methylation in both human solid tumors and hematological malignancies. However, the role of IRF8 in lung carcinoma remains elusive. In this study, we determined IRF8 epigenetic regulation, biological functions, and the signaling pathway involved in non-small cell lung cancer (NSCLC).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research