Hyperoside Protects Against Pressure Overload-Induced Cardiac Remodeling via the AKT Signaling Pathway | Zendy

Xiaofang Wang | Zendy; Yuan Liu | Zendy; Lili Xiao | Zendy; Ling Li | Zendy; Xiaoyan Zhao | Zendy; Lulu Yang | Zendy; Ning Chen | Zendy; Lu Gao | Zendy; Jinying Zhang | Zendy

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Hyperoside Protects Against Pressure Overload-Induced Cardiac Remodeling via the AKT Signaling Pathway

Author(s) -

Xiaofang Wang,

Yuan Liu,

Lili Xiao,

Ling Li,

Xiaoyan Zhao,

Lulu Yang,

Ning Chen,

Lu Gao,

Jinying Zhang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495368

Subject(s) - pressure overload , muscle hypertrophy , angiotensin ii , medicine , cardiac fibrosis , fibrosis , protein kinase b , ventricular remodeling , heart failure , cardiac function curve , endocrinology , pharmacology , blood pressure , signal transduction , chemistry , cardiac hypertrophy , biochemistry

Cardiac hypertrophy is a major predisposing factor for heart failure and sudden cardiac death. Hyperoside (Hyp), a flavonoid isolated from Rhododendron ponticum L., is a primary component of Chinese traditional patent medicines. Numerous studies have shown that Hyp exerts marked anti-viral, anti-inflammatory, anti-oxidant, anti-cancer, anti-ischemic, and particularly cardio-protective effects. However, the effects of Hyp on cardiac hypertrophy have not been explored. The aims of this study were to determine whether Hyp could protect against cardiac remodeling and to clarify the potential molecular mechanisms.

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