Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3 | Zendy

Fang He | Zendy; Huibin Liu | Zendy; Jing Guo | Zendy; Di Yang | Zendy; Yang Yu | Zendy; Jie Yu | Zendy; Xiuqing Yan | Zendy; Juan Hu | Zendy; Zhimin Du | Zendy

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Inhibition of MicroRNA-124 Reduces Cardiomyocyte Apoptosis Following Myocardial Infarction via Targeting STAT3

Author(s) -

Fang He,

Huibin Liu,

Jing Guo,

Di Yang,

Yang Yu,

Jie Yu,

Xiuqing Yan,

Juan Hu,

Zhimin Du

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000495173

Subject(s) - apoptosis , downregulation and upregulation , microrna , tunel assay , antagomir , gene silencing , flow cytometry , stat3 , western blot , viability assay , cancer research , microbiology and biotechnology , biology , chemistry , medicine , biochemistry , gene

MicroRNAs play an important role in regulating myocardial infarction (MI)-induced cardiac injury. MicroRNA-124 (miR-124) plays a vital role in regulating cellular proliferation, differentiation and apoptosis. Although the alteration of miR-124 was confirmed in peripheral blood of MI patients, little is known regarding the biological functions of miR-124 in cardiomyocytes. This study was designed to explore the role of miR-124 in MI and its underlying mechanisms.

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