Comprehensive Analysis of the Relationship Between RAS and RAF Mutations and MSI Status of Colorectal Cancer in Northeastern China | Zendy

Wenqi Li | Zendy; Huining Li | Zendy; Ruiqi Liu | Zendy; Xinxin Yang | Zendy; Yuhui Gao | Zendy; Yangyang Niu | Zendy; Jiashi Geng | Zendy; Yingwei Xue | Zendy; Xiaoming Jin | Zendy; Qi You | Zendy; Jingshu Geng | Zendy; Hongxue Meng | Zendy

Open Access

Comprehensive Analysis of the Relationship Between RAS and RAF Mutations and MSI Status of Colorectal Cancer in Northeastern China

Author(s) -

Wenqi Li,

Huining Li,

Ruiqi Liu,

Xinxin Yang,

Yuhui Gao,

Yangyang Niu,

Jiashi Geng,

Yingwei Xue,

Xiaoming Jin,

Qi You,

Jingshu Geng,

Hongxue Meng

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494649

Subject(s) - microsatellite instability , colorectal cancer , sanger sequencing , cancer research , mutation , cancer , medicine , oncology , biology , gene mutation , gene , chromosome instability , genetics , allele , microsatellite , chromosome

Colorectal cancer (CRC) is mainly caused by chromosomal instability (CIN) and microsatellite instability (MSI). The RAS and RAF genes are essential components of the CIN pathway, and several studies have found that RAS and RAF mutations are associated with MSI status in CRC. Here, we examined these three factors in CRC in Northeast China and aimed to reveal new details of the relationship between these mutations and MSI status.

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