Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling | Zendy

Michael Kittl | Zendy; Heidemarie Dobias | Zendy; Marlena Beyreis | Zendy; Tobias Kiesslich | Zendy; Christian Mayr | Zendy; Martin Gaisberger | Zendy; Markus Ritter | Zendy; Hubert Kerschbaum | Zendy; Martin Jakab | Zendy

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Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling

Author(s) -

Michael Kittl,

Heidemarie Dobias,

Marlena Beyreis,

Tobias Kiesslich,

Christian Mayr,

Martin Gaisberger,

Markus Ritter,

Hubert Kerschbaum,

Martin Jakab

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494646

Subject(s) - glycine , depolarization , glycine receptor , patch clamp , microbiology and biotechnology , membrane potential , reversal potential , chemistry , biophysics , biochemistry , biology , amino acid , receptor

The neutral, non-essential amino acid glycine has manifold functions and effects under physiological and pathophysiological conditions. Besides its function as a neurotransmitter in the central nervous system, glycine also exerts immunomodulatory effects and as an osmolyte it participates in cell volume regulation. During phagocytosis, glycine contributes to (local) cell volume-dependent processes like lamellipodium formation. Similar to the expansion of the lamellipodium we assume that glycine also affects the migration of microglial cells in a cell volume-dependent manner.

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