Dynamic Methylation Changes of DNA and H3K4 by RG108 Improve Epigenetic Reprogramming of Somatic Cell Nuclear Transfer Embryos in Pigs | Zendy

Yanhui Zhai | Zendy; Zhiren Zhang | Zendy; Hao Yu | Zendy; Li Su | Zendy; Gang Yao | Zendy; Xiaoling Ma | Zendy; Qi Li | Zendy; Xinglan An | Zendy; Sheng Zhang | Zendy; Ziyi Li | Zendy

Open Access

Dynamic Methylation Changes of DNA and H3K4 by RG108 Improve Epigenetic Reprogramming of Somatic Cell Nuclear Transfer Embryos in Pigs

Author(s) -

Yanhui Zhai,

Zhiren Zhang,

Hao Yu,

Li Su,

Gang Yao,

Xiaoling Ma,

Qi Li,

Xinglan An,

Sheng Zhang,

Ziyi Li

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494598

Subject(s) - somatic cell nuclear transfer , dna methylation , reprogramming , biology , microbiology and biotechnology , dna demethylation , epigenetics , dna methyltransferase , histone , histone methyltransferase , histone h3 , methyltransferase , methylation , embryo , blastocyst , embryogenesis , genetics , gene expression , dna , cell , gene

DNA methylation and histone modifications are essential epigenetic marks that can significantly affect the mammalian somatic cell nuclear transfer (SCNT) embryo development. However, the mechanisms by which the DNA methylation affects the epigenetic reprogramming have not been fully elucidated.

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