Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury | Zendy

Baokai Dou | Zendy; Wenjin Zhou | Zendy; Shichun Li | Zendy; Lixin Wang | Zendy; Ximin Wu | Zendy; Yiming Li | Zendy; Huida Guan | Zendy; Changhong Wang | Zendy; Shiguo Zhu | Zendy; Zunji Ke | Zendy; Cheng Huang | Zendy; Zhifei Wang | Zendy

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Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury

Author(s) -

Baokai Dou,

Wenjin Zhou,

Shichun Li,

Lixin Wang,

Ximin Wu,

Yiming Li,

Huida Guan,

Changhong Wang,

Shiguo Zhu,

Zunji Ke,

Cheng Huang,

Zhifei Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494587

Subject(s) - medicine , cxcl10 , extravasation , ischemia , infiltration (hvac) , chemokine , pharmacology , blood–brain barrier , evans blue , pathology , inflammation , immunology , central nervous system , physics , thermodynamics

Natural killer (NK) cells are among the first immune cells that respond to an ischemic insult in human brains. The infiltrated NK cells damage blood-brain barrier (BBB) and exacerbate brain infarction. Buyang Huanwu Decoction (BHD), a classic Chinese traditional herbal prescription, has long been used for the treatment of ischemic stroke. The present study investigated whether BHD can prevent brain infiltration of NK cells, attenuate BBB disruption and improve ischemic outcomes.

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