The Association and Clinical Significance of CDKN2A Promoter Methylation in Head and Neck Squamous Cell Carcinoma: a Meta-Analysis | Zendy

Chongchang Zhou | Zendy; Zhisen Shen | Zendy; Dong Ye | Zendy; Qun Li | Zendy; Hongxia Deng | Zendy; Huigao Liu | Zendy; Jinyun Li | Zendy

Open Access

The Association and Clinical Significance of CDKN2A Promoter Methylation in Head and Neck Squamous Cell Carcinoma: a Meta-Analysis

Author(s) -

Chongchang Zhou,

Zhisen Shen,

Dong Ye,

Qun Li,

Hongxia Deng,

Huigao Liu,

Jinyun Li

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494473

Subject(s) - cdkn2a , head and neck squamous cell carcinoma , oncology , medicine , methylation , cancer research , hazard ratio , carcinogenesis , dna methylation , odds ratio , cancer , biology , head and neck cancer , confidence interval , biochemistry , gene expression , gene

The association between cyclin-dependent kinase inhibitor 2A (CDKN2A) hypermethylation and head and neck squamous cell carcinoma (HNSCC) risk has been investigated by a number of studies. However, these studies have not demonstrated consistent results. Moreover, the role of CDKN2A methylation in HNSCC carcinogenesis and its clinical significance remain unclear.

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