Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy | Zendy

Xing-Rong An | Zendy; Xin Li | Zendy; Wei Wei | Zendy; Xiaoxue Li | Zendy; Ming Xu | Zendy

Open Access

Prostaglandin E1 Inhibited Diabetes-Induced Phenotypic Switching of Vascular Smooth Muscle Cells Through Activating Autophagy

Author(s) -

Xing-Rong An,

Xin Li,

Wei Wei,

Xiaoxue Li,

Ming Xu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494240

Subject(s) - autophagy , vascular smooth muscle , endocrinology , pi3k/akt/mtor pathway , medicine , protein kinase b , streptozotocin , osteopontin , biology , chemistry , diabetes mellitus , microbiology and biotechnology , phosphorylation , signal transduction , apoptosis , biochemistry , smooth muscle

The phenotype switching of vascular smooth muscle cells (VSMCs) was associated with the onset or progression of the atherogenic process in type 2 diabetes mellitus (T2DM). Alprostadil (Prostaglandin E1, PGE1) as a bioactive drug had a protective effect on vascular function. However, it is unknown whether PGE1 inhibited the phenotype switching in VSMCs via autophagy, which played a protective role in the vascular complications of diabetes.

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