Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model | Zendy

Rie Marunaka | Zendy; Akiyuki Taruno | Zendy; Toshiro Yamamoto | Zendy; Narisato Kanamura | Zendy; Yoshinori Marunaka | Zendy

Open Access

Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model

Author(s) -

Rie Marunaka,

Akiyuki Taruno,

Toshiro Yamamoto,

Narisato Kanamura,

Yoshinori Marunaka

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000494012

Subject(s) - epithelial sodium channel , tyrosine kinase , kinetics , chemistry , microbiology and biotechnology , tyrosine kinase inhibitor , protein kinase a , endocrinology , medicine , pharmacology , biophysics , phosphorylation , biology , signal transduction , biochemistry , sodium , physics , quantum mechanics , cancer , organic chemistry

Epithelial Na+ channels (ENaCs) play crucial roles in control of blood pressure by determining the total amount of renal Na+ reabsorption, which is regulated by various factors such as aldosterone, vasopressin, insulin and osmolality. The intracellular trafficking process of ENaCs regulates the amount of the ENaC-mediated Na+ reabsorption in the collecting duct of the kidney mainly by determining the number of ENaC expressed at the apical membrane of epithelial cells. Although we previously reported protein tyrosine kinases (PTKs) contributed to the ENaC-mediated epithelial Na+ reabsorption, we have no information on the role of PTKs in the intracellular ENaC trafficking.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research