The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures | Zendy

Ming-Chi Lai | Zendy; Kao-Min Lin | Zendy; Poh-Shiow Yeh | Zendy; ShengNan Wu | Zendy; ChinWei Huang | Zendy

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The Novel Effect of Immunomodulator-Glatiramer Acetate on Epileptogenesis and Epileptic Seizures

Author(s) -

Ming-Chi Lai,

Kao-Min Lin,

Poh-Shiow Yeh,

ShengNan Wu,

ChinWei Huang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493965

Subject(s) - pilocarpine , status epilepticus , epilepsy , epileptogenesis , hippocampal sclerosis , glatiramer acetate , medicine , hippocampus , hippocampal formation , anesthesia , multiple sclerosis , pharmacology , endocrinology , temporal lobe , immunology , psychiatry

Immunological mechanisms can be triggered as a response to central nervous system insults and can lead to seizures. In this study an investigation was made to determine if glatiramer acetate (GA), an immunomodulator currently used in the treatment of multiple sclerosis, could protect rats from pilocarpine-induced seizures and chronic epilepsy.

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