Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors | Zendy

Wei Yan | Zendy; Mingyue Tao | Zendy; Baofei Jiang | Zendy; Mengchu Yao | Zendy; Yali Jun | Zendy; Weijie Dai | Zendy; Zhuang Tang | Zendy; Yong Gao | Zendy; Li Zhang | Zendy; Xiaofei Chen | Zendy; Qilong Wang | Zendy

Open Access

Overcoming Drug Resistance in Colon Cancer by Aptamer-Mediated Targeted Co-Delivery of Drug and siRNA Using Grapefruit-Derived Nanovectors

Author(s) -

Wei Yan,

Mingyue Tao,

Baofei Jiang,

Mengchu Yao,

Yali Jun,

Weijie Dai,

Zhuang Tang,

Yong Gao,

Li Zhang,

Xiaofei Chen,

Qilong Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493960

Subject(s) - doxorubicin , in vivo , internalization , flow cytometry , cancer cell , multiple drug resistance , downregulation and upregulation , chemistry , apoptosis , cancer research , drug delivery , aptamer , in vitro , pharmacology , cancer , cell , microbiology and biotechnology , chemotherapy , biology , medicine , biochemistry , organic chemistry , gene , antibiotics

Multidrug resistance (MDR) is the most common cause of chemotherapy failure. Upregulation of P-glycoprotein (P-gp) is one of the main mechanisms underlying MDR.

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