Downregulation of MicroRNA-4463 Attenuates High-Glucose- and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS | Zendy

Xuemei He | Zendy; Chao Du | Zendy; Yan Zou | Zendy; Yang Long | Zendy; Can Huang | Zendy; Feng Chen | Zendy; Yanzheng He | Zendy; Xiangyu Zhou | Zendy

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Downregulation of MicroRNA-4463 Attenuates High-Glucose- and Hypoxia-Induced Endothelial Cell Injury by Targeting PNUTS

Author(s) -

Xuemei He,

Chao Du,

Yan Zou,

Yang Long,

Can Huang,

Feng Chen,

Yanzheng He,

Xiangyu Zhou

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493717

Subject(s) - downregulation and upregulation , microbiology and biotechnology , apoptosis , protein kinase b , cancer research , biology , chemistry , phosphorylation , biochemistry , gene

Vascular complications are the main reasons for disability and mortality associated with type 2 diabetes mellitus (T2DM) and numerous microRNAs (miRNAs) are involved in this process. Our previous study demonstrated that miR-4463 was increased in the plasma of T2DM patients combined with arteriosclerosis of low extremity artery (ASO). However, the role of miR-4463 remains unclear.

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