Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3β Pathway | Zendy

Xiaoye Fan | Zendy; Lidong Wang | Zendy; Jingbo Huang | Zendy; Hongming Lv | Zendy; Xuming Deng | Zendy; Xinxin Ci | Zendy

Open Access

Pterostilbene Reduces Acetaminophen-Induced Liver Injury by Activating the Nrf2 Antioxidative Defense System via the AMPK/Akt/GSK3β Pathway

Author(s) -

Xiaoye Fan,

Lidong Wang,

Jingbo Huang,

Hongming Lv,

Xuming Deng,

Xinxin Ci

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493655

Subject(s) - chemistry , resveratrol , pharmacology , protein kinase b , ampk , superoxide dismutase , glutathione , liver injury , aspartate transaminase , reactive oxygen species , pterostilbene , alanine transaminase , oxidative stress , protein kinase a , biochemistry , apoptosis , kinase , biology , endocrinology , alkaline phosphatase , enzyme

Pterostilbene (Pts), a natural dimethylated analog of resveratrol from blueberries, exerts antioxidative and anti-apoptotic effects in various diseases. This study aims to investigate the protective effects and mechanism of Pts against acetaminophen (APAP)-induced hepatotoxicity in vivo.

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