miR-191 Inhibition Induces Apoptosis Through Reactivating Secreted Frizzled-Related Protein-1 in Cholangiocarcinoma | Zendy

Pengcheng Kang | Zendy; Kaiming Leng | Zendy; Yueping Liu | Zendy; Yang Liu | Zendy; Yi Xu | Zendy; Wei Qin | Zendy; Jianjun Gao | Zendy; Zhidong Wang | Zendy; Sheng Tai | Zendy; Xiangyu Zhong | Zendy; Yunfu Cui | Zendy

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miR-191 Inhibition Induces Apoptosis Through Reactivating Secreted Frizzled-Related Protein-1 in Cholangiocarcinoma

Author(s) -

Pengcheng Kang,

Kaiming Leng,

Yueping Liu,

Yang Liu,

Yi Xu,

Wei Qin,

Jianjun Gao,

Zhidong Wang,

Sheng Tai,

Xiangyu Zhong,

Yunfu Cui

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493654

Subject(s) - apoptosis , frizzled , cancer research , wnt signaling pathway , biology , microbiology and biotechnology , chemistry , signal transduction , medicine , biochemistry

Cholangiocarcinoma (CCA) is one of the most common malignant tumors of the biliary tract originating from biliary epithelial cells. Although many therapeutic strategies have been developed to treat CCA, the survival rate for CCA patients is still quite low. Thus it is urgent to elucidate the pathogenesis of CCA and to explore novel therapeutic targets. miR-191 has been shown to be associated with many human solid cancers, but the function of miR-191 in CCA is still poorly understood.

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