Transient High-Glucose Stimulation Induces Persistent Inflammatory Factor Secretion from Rat Glomerular Mesangial Cells via an Epigenetic Mechanism | Zendy

Yunlei Deng | Zendy; Qiuling Fan | Zendy; Xu Wang | Zendy; Qianwen Zhao | Zendy; Xu Cao | Zendy; Li Xu | Zendy; Lining Wang | Zendy

Open Access

Transient High-Glucose Stimulation Induces Persistent Inflammatory Factor Secretion from Rat Glomerular Mesangial Cells via an Epigenetic Mechanism

Author(s) -

Yunlei Deng,

Qiuling Fan,

Xu Wang,

Qianwen Zhao,

Xu Cao,

Li Xu,

Lining Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493619

Subject(s) - medicine , endocrinology , mesangial cell , diabetic nephropathy , stimulation , western blot , biology , chemistry , diabetes mellitus , kidney , biochemistry , gene

Diabetic nephropathy is the one of the most serious microvascular complications of diabetes mellitus, and "metabolic memory" plays a vital role in the development of diabetic complications. To investigate the effect of epigenetics on metabolic memory, we analyzed the impact of transient high-glucose stimulation on the secretion of inflammatory factors from rat glomerular mesangial cells.

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