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The in Vitro Effect of Polyvinylpyrrolidone and Citrate Coated Silver Nanoparticles on Erythrocytic Oxidative Damage and Eryptosis
Author(s) -
Zannatul Ferdous,
Sumaya Beegam,
Saeed Tariq,
Badreldin H. Ali,
Abderrahim Nemmar
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000493460
Subject(s) - chemistry , lipid peroxidation , silver nanoparticle , hemolysis , oxidative stress , polyvinylpyrrolidone , glutathione , annexin , nanotoxicology , in vitro , biochemistry , catalase , pharmacology , microbiology and biotechnology , biophysics , toxicity , biology , immunology , nanoparticle , nanotechnology , materials science , enzyme , organic chemistry
Silver nanoparticles (AgNPs) are increasingly used as antimicrobial agents and drug carriers in various biomedical fields. AgNPs can encounter erythrocytes either directly following intravenous injection, or indirectly via translocation from the site of administration. However, information regarding the pathophysiological effects and possible mechanism of action of AgNPs on the erythrocytes are still inadequately studied. Thus, the aim of our study was to investigate the mechanism underlying the effect of coating and concentration of AgNPs on mouse erythrocytes in vitro.

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