Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway | Zendy

Xiaoli Wu | Zendy; Xiaoqiang Ding | Zendy; Zhishan Ding | Zendy; Ping Jia | Zendy

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Total Flavonoids from Leaves of Carya Cathayensis Ameliorate Renal Fibrosis via the miR-21/Smad7 Signaling Pathway

Author(s) -

Xiaoli Wu,

Xiaoqiang Ding,

Zhishan Ding,

Ping Jia

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493458

Subject(s) - smad , signal transduction , fibrosis , transforming growth factor , western blot , luciferase , transcription factor , in vivo , blot , chemistry , microbiology and biotechnology , cancer research , biology , transfection , medicine , pathology , gene , biochemistry , genetics

Renal tubulointerstitial fibrosis is the most common pathway of progressive kidney injury, leading to end-stage renal disease. At present, no effective prophylactic treatment method is available. This study investigated the anti-fibrotic effects of total flavonoids (TFs) extracted from leaves of Carya Cathayensis in vivo and in vitro, and explored the underlying mechanisms.

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