Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK | Zendy

Kodai Uematsu | Zendy; Yukiko Enomoto | Zendy; Takashi Onuma | Zendy; Masanori Tsujimoto | Zendy; Tomoaki Doi | Zendy; Rie MatsushimaNishiwaki | Zendy; Haruhiko Tokuda | Zendy; Shinji Ogura | Zendy; Hiroki Iida | Zendy; Osamu Kozawa | Zendy; Toru Iwama | Zendy

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Rac Regulates the TRAP-Induced Release of Phosphorylated-HSP27 from Human Platelets via p38 MAP Kinase but Not JNK

Author(s) -

Kodai Uematsu,

Yukiko Enomoto,

Takashi Onuma,

Masanori Tsujimoto,

Tomoaki Doi,

Rie MatsushimaNishiwaki,

Haruhiko Tokuda,

Shinji Ogura,

Hiroki Iida,

Osamu Kozawa,

Toru Iwama

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493456

Subject(s) - hsp27 , phosphorylation , p38 mitogen activated protein kinases , kinase , thrombin , protein kinase a , platelet , microbiology and biotechnology , mapk/erk pathway , platelet activation , platelet derived growth factor receptor , heat shock protein , chemistry , biology , biochemistry , growth factor , hsp70 , receptor , immunology , gene

Thrombin induces the activation of human platelets through protease-activated receptor (PAR) 1 and PAR4, and Rac, a member of the Rho family of small GTPases, is implicated in PAR activation. We previously reported that phosphorylated-heat shock protein 27 (HSP27) is released from the thrombin receptor-activating peptide (TRAP)-stimulated platelets of diabetic patients. In the present study, we investigated the role of Rac in the TRAP-elicited release of phosphorylated-HSP27 from human platelets.

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