Suppression of Long Non-Coding RNA LINC00652 Restores Sevoflurane-Induced Cardioprotection Against Myocardial Ischemia-Reperfusion Injury by Targeting GLP-1R Through the cAMP/PKA Pathway in Mice | Zendy

Shubo Zhang | Zendy; Tiejun Liu | Zendy; Guo-Hua Pu | Zendy; Bao-Yong Li | Zendy; Xiaozeng Gao | Zendy; Xiaoliang Han | Zendy

Open Access

Suppression of Long Non-Coding RNA LINC00652 Restores Sevoflurane-Induced Cardioprotection Against Myocardial Ischemia-Reperfusion Injury by Targeting GLP-1R Through the cAMP/PKA Pathway in Mice

Author(s) -

Shubo Zhang,

Tiejun Liu,

Guo-Hua Pu,

Bao-Yong Li,

Xiaozeng Gao,

Xiaoliang Han

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493450

Subject(s) - cardioprotection , reperfusion injury , medicine , creb , cardiac function curve , cyclic adenosine monophosphate , ischemia , apoptosis , endocrinology , pharmacology , biology , receptor , gene , heart failure , transcription factor , biochemistry

Long non-coding RNA (lncRNA) and glucagon-like peptide 1 receptor (GLP-1R) are crucial for heart development and for adult heart structural maintenance and function. Herein, we performed a study to explore the effect of lncRNA LINC00652 (LINC00652) on myocardial ischemia-reperfusion (I/R) injury by targeting GLP-1R through the cyclic adenosine monophosphate-protein kinase A (cAMP/PKA) pathway.

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