Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells | Zendy

Xin Chen | Zendy; Qianqian Yang | Zendy; Jinghong Chen | Zendy; Peiquan Zhang | Zendy; Qingtian Huang | Zendy; Xiaolan Zhang | Zendy; Yang Li | Zendy; Dacai Xu | Zendy; Chong Zhao | Zendy; Xuejun Wang | Zendy; Jinbao Liu | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Author(s) -

Xin Chen,

Qianqian Yang,

Jinghong Chen,

Peiquan Zhang,

Qingtian Huang,

Xiaolan Zhang,

Yang Li,

Dacai Xu,

Chong Zhao,

Xuejun Wang,

Jinbao Liu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000493041

Subject(s) - deubiquitinating enzyme , proteasome , viability assay , ubiquitin , apoptosis , chemistry , flow cytometry , microbiology and biotechnology , intracellular , cancer cell , cancer research , cell growth , biology , biochemistry , cancer , genetics , gene

The ubiquitin proteasome system (UPS) is responsible for the degradation of most intracellular proteins, and proteasomal deubiquitinases (DUBs) have recently been highlighted as novel anticancer targets. It is well documented that copper complexes can inhibit UPS function through targeting both 20S proteasome and proteasomal DUBs. The antineoplastic activities of silver complexes have received much attention, but the exact mechanisms are not fully elucidated. In this study, we aim to investigate the effects of a novel silver complex [Ag(S2CN(C2H5)2)]6 (AgDT) on UPS function and its anticancer potential in non-small cell lung cancer (NSCLC).

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research