AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia | Zendy

Xiaotao Yang | Zendy; Ping Xu | Zendy; Fumei Zhang | Zendy; Li Zhang | Zendy; Yangxi Zheng | Zendy; Mingyu Hu | Zendy; Lulu Wang | Zendy; Ting­-Li Han | Zendy; Chuan Peng | Zendy; Lianlian Wang | Zendy; Li Wen | Zendy; Yiwen Zeng | Zendy; Rufei Gao | Zendy; Yong Xia | Zendy; Chao Tong | Zendy; Zhu Yang | Zendy; Hongbo Qi | Zendy; Philip N. Baker | Zendy

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AMPK Hyper-Activation Alters Fatty Acids Metabolism and Impairs Invasiveness of Trophoblasts in Preeclampsia

Author(s) -

Xiaotao Yang,

Ping Xu,

Fumei Zhang,

Li Zhang,

Yangxi Zheng,

Mingyu Hu,

Lulu Wang,

Ting-Li Han,

Chuan Peng,

Lianlian Wang,

Li Wen,

Yiwen Zeng,

Rufei Gao,

Yong Xia,

Chao Tong,

Zhu Yang,

Hongbo Qi,

Philip N. Baker

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492995

Subject(s) - ampk , trophoblast , amp activated protein kinase , preeclampsia , protein kinase a , placenta , chemistry , biology , microbiology and biotechnology , endocrinology , medicine , kinase , fetus , pregnancy , genetics

Preeclampsia (PE) has long been assumed to be an ischemic disease of the placenta, although there is limited evidence as to how the ischemia impacts on the placenta. AMP-activated protein kinase (AMPK) is a key regulator of cellular energy metabolism and plays an important role in a variety of ischemic diseases by enhancing energy production. The present study investigated placental metabolism in PE, and the role of AMPK in regulating trophoblast function.

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