Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy | Zendy

Niina Piippo | Zendy; Eveliina Korhonen | Zendy; Maria Hytti | Zendy; Kati Kinnunen | Zendy; Kai Kaarniranta | Zendy; Anu Kauppinen | Zendy

Open Access

Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy

Author(s) -

Niina Piippo,

Eveliina Korhonen,

Maria Hytti,

Kati Kinnunen,

Kai Kaarniranta,

Anu Kauppinen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492886

Subject(s) - oxidative stress , inflammasome , bafilomycin , chemistry , microbiology and biotechnology , mg132 , extracellular , reactive oxygen species , intracellular , biochemistry , retinal pigment epithelium , autophagy , proteasome , biology , proteasome inhibitor , retinal , apoptosis , receptor

Previously, we demonstrated that blockade of the intracellular clearance systems in human retinal pigment epithelial (RPE) cells by MG-132 and bafilomycin A1 (BafA) induces NLRP3 inflammasome signaling. Here, we have explored the activation mechanisms behind this process. NLRP3 is an intracellular receptor detecting factors ranging from the endogenous alarmins and adenosine triphosphate (ATP) to ultraviolet radiation and solid particles. Due to the plethora of triggers, the activation of NLRP3 is often indirect and can be mediated through several alternative pathways. Potassium efflux, lysosomal rupture, and oxidative stress are currently the main mechanisms associated with many activators.

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