FOXO3 Inhibits Human Gastric Adenocarcinoma (AGS) Cell Growth by Promoting Autophagy in an Acidic Microenvironment | Zendy

Yuan Gao | Zendy; Weiwei Qi | Zendy; Libin Sun | Zendy; Jing Lv | Zendy; Wensheng Qiu | Zendy; Shihai Liu | Zendy

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FOXO3 Inhibits Human Gastric Adenocarcinoma (AGS) Cell Growth by Promoting Autophagy in an Acidic Microenvironment

Author(s) -

Yuan Gao,

Weiwei Qi,

Libin Sun,

Jing Lv,

Wensheng Qiu,

Shihai Liu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492884

Subject(s) - autophagy , foxo3 , transfection , cell , microbiology and biotechnology , cell culture , chemistry , viability assay , cancer cell , apoptosis , cell growth , tumor microenvironment , downregulation and upregulation , biology , cancer research , cancer , gene , biochemistry , tumor cells , genetics

Previous studies have shown that FOXO3, a member of the forkhead box O (FOXO) family, regulates autophagy in various cells. To date, whether the induction of autophagy in gastric cancer (GC) cells is triggered by an acidic microenvironment is unclear. Little is known about the relationship between FOXO3 and acidic microenvironments in GC. The aims of our study were to investigate the roles of FOXO3 and the acidic microenvironment in autophagy and to determine how FOXO3 and the acidic microenvironment regulate GC cell growth through autophagy.

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