The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways | Zendy

Congxiang Shen | Zendy; Fang Chen | Zendy; Huigang Wang | Zendy; Guanxue Li | Zendy; Chaosheng Yu | Zendy; Xiaoqi Wang | Zendy; Zhong Wen | Zendy

Open Access

The Pinx1 Gene Downregulates Telomerase and Inhibits Proliferation of CD133+ Cancer Stem Cells Isolated from a Nasopharyngeal Carcinoma Cell Line by Regulating Trfs and Mad1/C-Myc/p53 Pathways

Author(s) -

Congxiang Shen,

Fang Chen,

Huigang Wang,

Guanxue Li,

Chaosheng Yu,

Xiaoqi Wang,

Zhong Wen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492878

Subject(s) - homeobox protein nanog , cancer research , cancer stem cell , biology , cd44 , telomerase , carcinogenesis , sox2 , nasopharyngeal carcinoma , cell growth , metastasis , stem cell , telomerase reverse transcriptase , cancer , microbiology and biotechnology , cell , induced pluripotent stem cell , medicine , transcription factor , radiation therapy , embryonic stem cell , biochemistry , genetics , gene

Cancer stem cells (CSCs) are important factors for the continuous growth, recurrence, and metastasis of malignant tumors. They are responsible for the ineffectiveness of traditional radiotherapy and chemotherapy toward malignant tumors. Currently, stem cells or side-population cells have been isolated from many cancer cell lines and malignant tumor tissues, including nasopharyngeal carcinoma. Exploring the biological characteristics of CSCs for CSC-targeted therapy has gained importance. CSCs possess higher telomerase activity; thus, the use of the gene encoding telomerase inhibitor PinX1 gene to target telomerase in CSCs and inhibit proliferation, invasion, and metastasis of CSCs has become an important means for the treatment of malignant tumors. PinX1 may regulate complex pathways, including TRF1, Mad1/c-Myc, and p53.

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