Imperatorin Targets MCL-1 to Sensitize CD133+ Lung Cancer Cells to γδ-T Cell-Mediated Cytotoxicity | Zendy

Changxuan You | Zendy; Yang Yu | Zendy; Beili Gao | Zendy

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Imperatorin Targets MCL-1 to Sensitize CD133+ Lung Cancer Cells to γδ-T Cell-Mediated Cytotoxicity

Author(s) -

Changxuan You,

Yang Yu,

Beili Gao

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492874

Subject(s) - cytotoxicity , cancer research , lung cancer , imperatorin , medicine , cancer , cell , apoptosis , chemistry , pharmacology , in vitro , biochemistry , high performance liquid chromatography , chromatography

CD133+ cancer cells display low sensitivity to anti-cancer treatment; thus, combination treatment with adjuvant drugs is required to improve the efficiency of cancer therapy. The aim of this study was to explore the effect of imperatorin, a linear furanocoumarin compound, on γδ T cell-mediated cytotoxicity against CD133+ lung cancer cells.

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