Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14 | Zendy

Daifeng Lu | Zendy; Chuandong Yang | Zendy; Zhitao Zhang | Zendy; Yu Cong | Zendy; Mochao Xiao | Zendy

Open Access

Knockdown of Linc00515 Inhibits Multiple Myeloma Autophagy and Chemoresistance by Upregulating miR-140-5p and Downregulating ATG14

Author(s) -

Daifeng Lu,

Chuandong Yang,

Zhitao Zhang,

Yu Cong,

Mochao Xiao

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492690

Subject(s) - autophagy , gene knockdown , melphalan , multiple myeloma , cancer research , flow cytometry , chemistry , mtt assay , microbiology and biotechnology , medicine , cell , biology , apoptosis , immunology , biochemistry

The purpose of our experiments was to investigate the targeting relationship of linc00515, miR-140-5p and ATG14 and to explore the roles of linc00515, miR-140-5p and ATG14 in autophagy and chemoresistance of melphalan-resistant multiple myeloma cells.

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