CD38 Deficiency Protects Heart from High Fat Diet-Induced Oxidative Stress Via Activating Sirt3/FOXO3 Pathway | Zendy

Lingfang Wang | Zendy; CongCong Huang | Zendy; YunFei Xiao | Zendy; XiaoHui Guan | Zendy; XiaoNv Wang | Zendy; Qing Cao | Zendy; Yu Liu | Zendy; Xuan Huang | Zendy; Libin Deng | Zendy; KeYu Deng | Zendy; HongBo Xin | Zendy

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CD38 Deficiency Protects Heart from High Fat Diet-Induced Oxidative Stress Via Activating Sirt3/FOXO3 Pathway

Author(s) -

Lingfang Wang,

CongCong Huang,

YunFei Xiao,

XiaoHui Guan,

XiaoNv Wang,

Qing Cao,

Yu Liu,

Xuan Huang,

Libin Deng,

KeYu Deng,

HongBo Xin

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492651

Subject(s) - sod2 , oxidative stress , sirt3 , reactive oxygen species , endocrinology , glutathione , medicine , chemistry , cd38 , superoxide dismutase , mitochondrial ros , biology , nad+ kinase , biochemistry , microbiology and biotechnology , sirtuin , enzyme , stem cell , cd34

Previous studies showed that CD38 deficiency protected heart from ischemia/reperfusion injury and high fat diet (HFD)-induced obesity in mice. However, the role of CD38 in HFD-induced heart injury remains unclear. In the present study, we have investigated the effects and mechanisms of CD38 deficiency on HFD-induced heart injury.

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