Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death | Zendy

Shenglong Zhu | Zendy; Ninghan Feng | Zendy; Guangxiao Lin | Zendy; Yuelin Tong | Zendy; Xuan Jiang | Zendy; Qin Yang | Zendy; Shunhe Wang | Zendy; Wei Chen | Zendy; Zhao He | Zendy; Yong Q. Chen | Zendy

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Metabolic Shift Induced by ω -3 PUFAs and Rapamycin Lead to Cancer Cell Death

Author(s) -

Shenglong Zhu,

Ninghan Feng,

Guangxiao Lin,

Yuelin Tong,

Xuan Jiang,

Qin Yang,

Shunhe Wang,

Wei Chen,

Zhao He,

Yong Q. Chen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492648

Subject(s) - polyunsaturated fatty acid , cancer research , in vivo , cancer , glutamine , pharmacology , biology , cancer cell , programmed cell death , breast cancer , autophagy , apoptosis , chemistry , medicine , biochemistry , fatty acid , microbiology and biotechnology , amino acid

Rapamycin (Rp), the main mammalian target of rapamycin complex inhibitor, is a promising therapeutic agent for breast cancer. However, metabolic disorders and drug resistance reduce its efficacy. Epidemiological, clinical, and experimental studies have demonstrated that omega-3 polyunsaturated fatty acids (ω-3 PUFAs) significantly reduce the incidence and mortality of breast cancer and improve metabolic disorders.

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