Open AccessEarly Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma
Author(s) -
Wael Al Zoughbi,
Silvia Schauer,
Martin Pichler,
Gerald Höefler
Publication year - 2018
Publication title -
pathobiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.941
H-Index - 53
eISSN - 1423-0291
pISSN - 1015-2008
DOI - 10.1159/000492433
Subject(s) - foxo1 , biology , cancer research , transcription factor , carcinogenesis , pancreatic cancer , tissue microarray , foxa1 , cancer , gene , genetics
Forkhead transcription factor, O subgroup, member 1 (FOXO1) is a regulatory protein that plays an essential role in cellular homeostasis. A biological function as a tumor suppressor has been proposed. Here, we examined FOXO1 expression in human pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions.
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