TRPC6-Mediated Ca2+ Signaling is Required for Hypoxia-Induced Autophagy in Human Podocytes | Zendy

Tianrong Ji | Zendy; Chengwei Zhang | Zendy; Linlin Ma | Zendy; Qin Wang | Zendy; Li Zou | Zendy; Kexin Meng | Zendy; Rui Zhang | Zendy; Jundong Jiao | Zendy

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TRPC6-Mediated Ca2+ Signaling is Required for Hypoxia-Induced Autophagy in Human Podocytes

Author(s) -

Tianrong Ji,

Chengwei Zhang,

Linlin Ma,

Qin Wang,

Li Zou,

Kexin Meng,

Rui Zhang,

Jundong Jiao

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492351

Subject(s) - trpc6 , autophagy , microbiology and biotechnology , hypoxia (environmental) , intracellular , signal transduction , ampk , chemistry , activator (genetics) , biology , protein kinase a , kinase , transient receptor potential channel , receptor , biochemistry , apoptosis , organic chemistry , oxygen

Intracellular Ca2+ signaling plays an important role in the regulation of autophagy. However, very little is known about the role of Ca2+ influx, which is induced by plasma membrane Ca2+ channels. Our previous study showed that transient receptor potential canonical channel-6 (TRPC6), a major Ca2+ influx pathway in podocytes, was activated by hypoxia. Here, we investigated whether TRPC6 is involved in hypoxia-induced autophagy in cultured human podocytes.

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