Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells | Zendy

HsinHan Chang | Zendy; YuChen Cheng | Zendy; WenChiuan Tsai | Zendy; Min-Jen Tsao | Zendy; Ying Chen | Zendy

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Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells

Author(s) -

HsinHan Chang,

YuChen Cheng,

WenChiuan Tsai,

Min-Jen Tsao,

Ying Chen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492293

Subject(s) - glioma , cancer research , apoptosis , biology , cell migration , cell growth , blot , cell culture , microbiology and biotechnology , gene , biochemistry , genetics

Glioblastoma, also known as glioblastoma multiforme (GBM), is a fast-growing type of tumor that is the most aggressive brain malignancy in adults. According to GEO profile analysis, patients with high transient receptor potential canonical 3 (TRPC3) expression have poor survival rates. The aim of this study is to evaluate the effects of Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), a selective TRPC3 channel blocker, on the proliferation and migration of human glioblastoma cells.

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