Knockdown of Mir-135b Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Apoptosis Through Increase of FOXO1 | Zendy

Qin Yan | Zendy; Longhai Li | Zendy; Fang Wang | Zendy; Xinyi Zhou | Zendy; Yankui Liu | Zendy; Yuan Yin | Zendy; Xiaowei Qi | Zendy

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Knockdown of Mir-135b Sensitizes Colorectal Cancer Cells to Oxaliplatin-Induced Apoptosis Through Increase of FOXO1

Author(s) -

Qin Yan,

Longhai Li,

Fang Wang,

Xinyi Zhou,

Yankui Liu,

Yuan Yin,

Xiaowei Qi

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000492284

Subject(s) - oxaliplatin , gene knockdown , cancer research , apoptosis , colorectal cancer , microrna , downregulation and upregulation , mtt assay , cell growth , chemistry , cancer , medicine , biochemistry , gene

Aberrant expression of microRNAs (miRNAs) is found to be responsible for tumorigenesis, cancer development and chemoresistance. Although oxaliplatin is an effective chemotherapeutic drug for treatment of colorectal cancer (CRC), CRC cells can develop some mechanisms to evade oxaliplatin-induced cell death. It is urgent to explore the novel strategies to increase the chemosensitivity of CRC cells.

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