Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells | Zendy

Chen Ping | Zendy; Luo Xiaoting | Zendy; Che Zhihui | Zendy; Zhang Wenli | Zendy; Liu Fuchen | Zendy; Hou Daisen | Zendy; Yang Dongqin | Zendy; Liu Jie | Zendy

Open Access

Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells

Author(s) -

Chen Ping,

Luo Xiaoting,

Che Zhihui,

Zhang Wenli,

Liu Fuchen,

Hou Daisen,

Yang Dongqin,

Liu Jie

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491979

Subject(s) - retracted paper

Regulator of cullins-1 (ROC1) is a pivotal component of cullin-RING E3 ubiquitin ligases, which help to regulate distinct cellular processes by governing the degradation of various substrates. Because the role of ROC1 in gastric cancer is largely uncharacterized, we investigated the relationship between ROC1 expression and the prognosis of gastric cancer patients and explored the biological function of ROC1 and its underlying mechanisms in gastric cancer.

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