Human β3-Adrenoreceptor is Resistant to Agonist-Induced Desensitization in Renal Epithelial Cells | Zendy

Serena Milano | Zendy; Andrea Gerbino | Zendy; Giorgia Schena | Zendy; Monica Carmosino | Zendy; Maria Svelto | Zendy; Giuseppe Procino | Zendy

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Human β3-Adrenoreceptor is Resistant to Agonist-Induced Desensitization in Renal Epithelial Cells

Author(s) -

Serena Milano,

Andrea Gerbino,

Giorgia Schena,

Monica Carmosino,

Maria Svelto,

Giuseppe Procino

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491916

Subject(s) - agonist , stimulation , internalization , downregulation and upregulation , receptor , mirabegron , endocrinology , medicine , desensitization (medicine) , arginine vasopressin receptor 2 , homologous desensitization , chemistry , pharmacology , microbiology and biotechnology , biology , antagonist , overactive bladder , biochemistry , alternative medicine , pathology , gene

We recently showed that the β3-adrenoreceptor (β3AR) is expressed in mouse kidney collecting ducts (CD) cells along with the type-2 vasopressin receptor (AVPR2). Interestingly, a single injection of a β3AR selective agonist promotes a potent antidiuretic effect in mice. Before considering the feasibility of chronic β3AR agonism to induce antidiuresis in vivo, we aimed to evaluate in vitro the signaling and desensitization profiles of human β3AR.

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