Activation of Cyclooxygenase-2 by ATF4 During Endoplasmic Reticulum Stress Regulates Kidney Podocyte Autophagy Induced by Lupus Nephritis | Zendy

Juan Jin | Zendy; Li Zhao | Zendy; Wenli Zou | Zendy; Wei Shen | Zendy; Hongjuan Zhang | Zendy; Qiang He | Zendy

Open Access

Activation of Cyclooxygenase-2 by ATF4 During Endoplasmic Reticulum Stress Regulates Kidney Podocyte Autophagy Induced by Lupus Nephritis

Author(s) -

Juan Jin,

Li Zhao,

Wenli Zou,

Wei Shen,

Hongjuan Zhang,

Qiang He

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491904

Subject(s) - podocyte , endoplasmic reticulum , autophagy , lupus nephritis , unfolded protein response , cyclooxygenase , medicine , microbiology and biotechnology , nephritis , kidney , endocrinology , cancer research , chemistry , biology , apoptosis , proteinuria , enzyme , biochemistry , disease

Autophagy plays an essential role in lupus nephritis (LN)-induced kidney injury, although the mechanism of action remains obscure. We investigated the role of cyclooxygenase-2 (COX-2) and the ATF4 endoplasmic reticulum (ER) stress pathway in LN-induced podocyte autophagy.

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