The Impact of Using Genotyped Reagent Red Blood Cells in Antibody Identification | Zendy

Erwin A. Scharberg | Zendy; Gabi Rink | Zendy; Jan Portegys | Zendy; Sina Rothenberger | Zendy; Nicole Gillhuber | Zendy; Ekkehard Richter | Zendy; Peter Bugert | Zendy

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The Impact of Using Genotyped Reagent Red Blood Cells in Antibody Identification

Author(s) -

Erwin A. Scharberg,

Gabi Rink,

Jan Portegys,

Sina Rothenberger,

Nicole Gillhuber,

Ekkehard Richter,

Peter Bugert

Publication year - 2018

Publication title -

transfusion medicine and hemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.971

H-Index - 39

eISSN - 1660-3818

pISSN - 1660-3796

DOI - 10.1159/000491884

Subject(s) - antigen , antibody , serology , red blood cell , immunology , genotype , whole blood , medicine , blood transfusion , rh blood group system , microbiology and biotechnology , virology , biology , gene , genetics

The detection and identification of antibodies to red blood cell (RBC) antigens is one of the most important and challenging issues in transfusion medicine. Up to date there are 354 RBC antigens recognized by the International Society of Blood Transfusion (ISBT). The reagent RBCs used in commercial antibody screening and identification panels however are usually serologically typed for up to 40 clinically important antigens. Thus the identification of many antibody specificities remains impossible when using reagent RBCs with only limited information about their antigens. To improve the pre-transfusion diagnostics, we developed antibody identification panels with reagent RBCs serologically typed for 26 antigens and additionally genotyped for 30 blood group alleles.

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