Gli2 Mediated Activation of Hedgehog Signaling Attenuates Acute Pancreatitis via Balancing Inflammatory Cytokines in Mice | Zendy

Zhiqiang Liu | Zendy; Kun Lai | Zendy; Ying Xie | Zendy; Xuemei He | Zendy; Xiangyu Zhou | Zendy

Open Access

Gli2 Mediated Activation of Hedgehog Signaling Attenuates Acute Pancreatitis via Balancing Inflammatory Cytokines in Mice

Author(s) -

Zhiqiang Liu,

Kun Lai,

Ying Xie,

Xuemei He,

Xiangyu Zhou

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000491668

Subject(s) - hedgehog signaling pathway , acute pancreatitis , gli2 , inflammation , signal transduction , proinflammatory cytokine , medicine , cancer research , smoothened , pancreatitis , hedgehog , pharmacology , chemistry , endocrinology , microbiology and biotechnology , immunology , biology

Inflammatory response is a determinant in the pathological progression of acute pancreatitis (AP). Previous studies have shown that the activation of hedgehog (Hh) signaling is a remarkable change in caerulein-induced AP. However, the relationship between Hh signaling and inflammation is largely ambiguous.

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